Continuous culture in combined backmix-plug-flow-tubular-loop fermentor configurations
نویسندگان
چکیده
منابع مشابه
Continuous Crystallization of Proteins in a Tubular Plug-Flow Crystallizer
Protein crystals have many important applications in many fields, including pharmaceutics. Being more stable than other formulations, and having a high degree of purity and bioavailability, they are especially promising in the area of drug delivery. In this contribution, the development of a continuously operated tubular crystallizer for the production of protein crystals has been described. Us...
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Crystallization processes in the pharmaceutical industry are usually designed to obtain crystals with controlled size, shape, purity, and polymorphic form. Knowledge of the process conditions required to fabricate crystals with controlled characteristics is critical during process development. In this work, continuous crystallization of Ketoconazole, Flufenamic Acid, and L-Glutamic Acid in a no...
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There are innumerable varieties of devices available for the supply of fluid media to continuous culture systems. The unit presented here offers the advantage of being an inexpensive system with a high degree of reliability. No moving parts or pumps are required, and functional models can be constructed from routine laboratory ware. The primary problem with gravity flow or "drip" systems has be...
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A small laboratory fermentor which employs mechanical agitation for the dispersion of air introduced under pressure has previously been described by Feustel and Humfeld (1946). This fermentor has an operating capacity of 500 to 2,000 ml and has been found very useful for small-scale, yeast-culturing investigations, as well as for studies on the production of subtilin activity by Bacillus subtil...
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ژورنال
عنوان ژورنال: Biotechnology and Bioengineering
سال: 1982
ISSN: 0006-3592,1097-0290
DOI: 10.1002/bit.260241019